Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC031
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-07-21 15:48
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl a 250mg 4x1/2 caps Madopar HBS 2 uvece pre spavanja

Overall Assessment

non PD

Subject performance similar to non PD population

Clinical context

In the clinical reference population, 20 individuals with a value less than 0.58 were subsequently diagnosed with PD. That is, 47.62% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.58 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 26, 'TN': 22, 'TP': 16, 'FP': 8}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 24, 'TN': 20, 'TP': 18, 'FP': 10}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 7, 'TN': 8, 'TP': 35, 'FP': 22}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 9, 'TN': 7, 'TP': 33, 'FP': 23}

Test Battery Details

Circle

numCircles 9
timePerCircleMean 4.82667
timePerCircleCoV 0.24886
timePerCircleSlope 0.0183702
meanError 2.2352
tremorFreq 6.93359
tremorRelPower 48.3746
tremorGyroAmpMean 0.0706486
tremorGyroAmpSlope -0.0157867
tremorGyroAmpCoV 0.43612
tremorCoordAmpMean 0.152073
tremorCoordAmpSlope -0.00828523
tremorCoordAmpCoV 0.377489
tremorAccAmpMean 0.122548
tremorAccAmpSlope -0.00936099
tremorAccAmpCoV 0.392622
tremorPcRelVar 0.716964
tremorPcX 0.533153
tremorPcY 0.846019

Circle Segment 1

Duration 5.48 s, Accuracy Estimate 1.49 (lower is better)

Circle Segment 2

Duration 4.52 s, Accuracy Estimate 2.014 (lower is better)

Circle Segment 3

Duration 4.4 s, Accuracy Estimate 2.076 (lower is better)

Circle Segment 4

Duration 4.12 s, Accuracy Estimate 2.498 (lower is better)

Circle Segment 5

Duration 4.2 s, Accuracy Estimate 2.596 (lower is better)

Circle Segment 6

Duration 4.2 s, Accuracy Estimate 2.071 (lower is better)

Circle Segment 7

Duration 4.36 s, Accuracy Estimate 1.996 (lower is better)

Circle Segment 8

Duration 7.84 s, Accuracy Estimate 3.004 (lower is better)

Circle Segment 9

Duration 4.32 s, Accuracy Estimate 2.372 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 12.6
timePerSpiralCoV 0.09911
timePerSpiralSlope -0.0269745
meanError 2.3909
tremorFreq 6.73828
tremorRelPower 39.212
tremorGyroAmpMean 0.0689724
tremorGyroAmpSlope 0.000508805
tremorGyroAmpCoV 0.395923
tremorCoordAmpMean 0.160127
tremorCoordAmpSlope 0.00122923
tremorCoordAmpCoV 0.35307
tremorAccAmpMean 0.131379
tremorAccAmpSlope 0.000717932
tremorAccAmpCoV 0.368636
tremorPcRelVar 0.672598
tremorPcX -0.392736
tremorPcY -0.919651

Spiral Segment 1

Duration 14.84 s, Accuracy Estimate 2.257 (lower is better)

Spiral Segment 2

Duration 14.72 s, Accuracy Estimate 2.197 (lower is better)

Spiral Segment 3

Duration 12.8 s, Accuracy Estimate 2.301 (lower is better)

Spiral Segment 4

Duration 11.96 s, Accuracy Estimate 2.327 (lower is better)

Spiral Segment 5

Duration 12.04 s, Accuracy Estimate 2.361 (lower is better)

Spiral Segment 6

Duration 12.52 s, Accuracy Estimate 2.465 (lower is better)

Spiral Segment 7

Duration 12.64 s, Accuracy Estimate 2.349 (lower is better)

Spiral Segment 8

Duration 11.4 s, Accuracy Estimate 2.665 (lower is better)

Spiral Segment 9

Duration 11.36 s, Accuracy Estimate 2.469 (lower is better)

Spiral Segment 10

Duration 11.72 s, Accuracy Estimate 2.518 (lower is better)

Elel

eDurationMean 0.446719
eDurationStd 0.114502
eDurationStdnorm 0.256317
eDurationMedian 0.41
eDurationQuartdelta 0.12
eDurationQuartdeltanorm 0.292683
eDurationKurt 7.30331
eDurationTrenddiff -0.055
eDurationTrendratio 0.878453
eWidthMean 3.13341
eWidthStd 1.33392
eWidthStdnorm 0.425708
eWidthMedian 2.808
eWidthQuartdelta 1.9305
eWidthQuartdeltanorm 0.6875
eWidthKurt 4.13684
eWidthTrenddiff 0.351
eWidthTrendratio 1.13333
eHeightMean 7.605
eHeightStd 1.45071
eHeightStdnorm 0.190758
eHeightMedian 7.371
eHeightQuartdelta 2.574
eHeightQuartdeltanorm 0.349206
eHeightKurt 1.72845
eHeightTrenddiff -1.053
eHeightTrendratio 0.868613
eAspectMean 0.410052
eAspectStd 0.140082
eAspectStdnorm 0.341619
eAspectMedian 0.409586
eAspectQuartdelta 0.16568
eAspectQuartdeltanorm 0.404506
eAspectKurt 3.20812
eAspectTrenddiff 0.0761335
eAspectTrendratio 1.21811
eSlantMean 0.073399
eSlantStd 0.158658
eSlantStdnorm 2.16158
eSlantMedian 0.0999169
eSlantQuartdelta 0.218162
eSlantQuartdeltanorm 2.18344
eSlantKurt 2.53479
eSlantTrenddiff 0.0599381
eRtopMean 0.792159
eRtopStd 0.137422
eRtopStdnorm 0.173478
eRtopMedian 0.820451
eRtopQuartdelta 0.151079
eRtopQuartdeltanorm 0.184141
eRtopKurt 5.67746
eRtopTrenddiff -0.0582816
eRbotMean 0.710036
eRbotStd 0.420476
eRbotStdnorm 0.59219
eRbotMedian 0.602326
eRbotQuartdelta 0.391317
eRbotQuartdeltanorm 0.649677
eRbotKurt 5.21097
eRbotTrenddiff -0.168557
eRrightMean 0.877678
eRrightStd 0.130965
eRrightStdnorm 0.149218
eRrightMedian 0.895425
eRrightQuartdelta 0.103654
eRrightQuartdeltanorm 0.115759
eRrightKurt 13.8043
eRrightTrenddiff -0.0391667
eRleftMean 0.327471
eRleftStd 0.141186
eRleftStdnorm 0.431141
eRleftMedian 0.323383
eRleftQuartdelta 0.157129
eRleftQuartdeltanorm 0.48589
eRleftKurt 5.14632
eRleftTrenddiff -0.0704047
lDurationMean 0.525735
lDurationStd 0.0865862
lDurationStdnorm 0.164695
lDurationMedian 0.5275
lDurationQuartdelta 0.105
lDurationQuartdeltanorm 0.199052
lDurationKurt 3.7598
lDurationTrenddiff -0.07
lDurationTrendratio 0.869159
lWidthMean 3.54441
lWidthStd 1.26063
lWidthStdnorm 0.355667
lWidthMedian 3.393
lWidthQuartdelta 1.287
lWidthQuartdeltanorm 0.37931
lWidthKurt 10.8142
lWidthTrenddiff -0.234
lWidthTrendratio 0.933333
lHeightMean 13.104
lHeightStd 3.12142
lHeightStdnorm 0.238203
lHeightMedian 12.402
lHeightQuartdelta 1.755
lHeightQuartdeltanorm 0.141509
lHeightKurt 7.6979
lHeightTrenddiff -0.351
lHeightTrendratio 0.971963
lAspectMean 0.275049
lAspectStd 0.0908203
lAspectStdnorm 0.330197
lAspectMedian 0.277559
lAspectQuartdelta 0.0974755
lAspectQuartdeltanorm 0.351188
lAspectKurt 9.78794
lAspectTrenddiff 0.0130629
lAspectTrendratio 1.0482
lSlantMean 0.00782959
lSlantStd 0.111786
lSlantStdnorm 14.2774
lSlantMedian 0
lSlantQuartdelta 0.117877
lSlantQuartdeltanorm 15.0553
lSlantKurt 3.01971
lSlantTrenddiff 0.0838037
lRtopMean 0.807825
lRtopStd 0.133566
lRtopStdnorm 0.16534
lRtopMedian 0.820451
lRtopQuartdelta 0.191964
lRtopQuartdeltanorm 0.233974
lRtopKurt 2.69902
lRtopTrenddiff 0.121008
lRbotMean 0.867245
lRbotStd 0.474569
lRbotStdnorm 0.547214
lRbotMedian 0.779514
lRbotQuartdelta 0.440341
lRbotQuartdeltanorm 0.564892
lRbotKurt 11.1677
lRbotTrenddiff -0.157509
lRrightMean 0.889075
lRrightStd 0.109395
lRrightStdnorm 0.123044
lRrightMedian 0.92558
lRrightQuartdelta 0.134097
lRrightQuartdeltanorm 0.144879
lRrightKurt 9.23027
lRrightTrenddiff 0.0407682
lRleftMean 0.356268
lRleftStd 0.167344
lRleftStdnorm 0.469714
lRleftMedian 0.340426
lRleftQuartdelta 0.272998
lRleftQuartdeltanorm 0.801931
lRleftKurt 2.10408
lRleftTrenddiff -0.193578

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

FITTS Short Modified

meanTouchScore 0.640698
sumTouchScores 21.143
meanMovementTime 0.597031
numTouches 33
undershootPercentage 0
overshootPercentage 48.4848

FITTS Long Modified

meanTouchScore 0.745
sumTouchScores 15.645
meanMovementTime 0.7545
numTouches 21
undershootPercentage 4.7619
overshootPercentage 38.0952

ZigZag

numZigzags 6
timePerZigzagMean 12
timePerZigzagCoV 0.155349
timePerZigzagSlope -0.0740952
meanError 3.33887
tremorFreq 6.34766
tremorRelPower 36.1915
tremorGyroAmpMean 0.102489
tremorGyroAmpSlope -0.00111361
tremorGyroAmpCoV 0.297137
tremorCoordAmpMean 0.215518
tremorCoordAmpSlope 0.001801
tremorCoordAmpCoV 0.307014
tremorAccAmpMean 0.173715
tremorAccAmpSlope 0.00100007
tremorAccAmpCoV 0.291184
tremorPcRelVar 0.882814
tremorPcX 0.122813
tremorPcY 0.99243

ZigZag Segment 1

Duration 15.08 s, Accuracy Estimate 2.509 (lower is better)

ZigZag Segment 2

Duration 13.52 s, Accuracy Estimate 2.844 (lower is better)

ZigZag Segment 3

Duration 11.16 s, Accuracy Estimate 3.769 (lower is better)

ZigZag Segment 4

Duration 10.8 s, Accuracy Estimate 3.602 (lower is better)

ZigZag Segment 5

Duration 11.0 s, Accuracy Estimate 3.548 (lower is better)

ZigZag Segment 6

Duration 10.44 s, Accuracy Estimate 3.761 (lower is better)

ZigZag Offset

numZigzags 6
timePerZigzagMean 12.9933
timePerZigzagCoV 0.13203
timePerZigzagSlope -0.0224291
zigzagHeightMean 53.1054
zigzagHeightCoV 0.132173
zigzagHeightSlope -0.00570923
meanError 0.0510899
tremorFreq 6.34766
tremorRelPower 41.8834
tremorGyroAmpMean 0.0800189
tremorGyroAmpSlope 0.00131234
tremorGyroAmpCoV 0.329004
tremorCoordAmpMean 0.180013
tremorCoordAmpSlope 0.00172722
tremorCoordAmpCoV 0.354276
tremorAccAmpMean 0.157146
tremorAccAmpSlope 0.0015324
tremorAccAmpCoV 0.326579
tremorPcRelVar 0.865674
tremorPcX 0.0599327
tremorPcY -0.998202

ZigZag Offset Segment 1

Duration 11.76 s, Accuracy Estimate 0.058 (lower is better)

ZigZag Offset Segment 2

Duration 15.36 s, Accuracy Estimate 0.033 (lower is better)

ZigZag Offset Segment 3

Duration 12.8 s, Accuracy Estimate 0.079 (lower is better)

ZigZag Offset Segment 4

Duration 13.8 s, Accuracy Estimate 0.039 (lower is better)

ZigZag Offset Segment 5

Duration 13.76 s, Accuracy Estimate 0.03 (lower is better)

ZigZag Offset Segment 6

Duration 10.48 s, Accuracy Estimate 0.068 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.78}
RanFor {‘RanFor_class’: ‘NOT PD’, ‘RanFor_score’: 0.58}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.9967362902287964}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9183142468455305}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.3652865082052834}